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De-Sexing Kids Will Stunt Their Brains
endogenous sex hormones are neuromodulators not toxins to suppress
sex hormones affect far more than just the sex organs
Puberty Blocker is the progressive euphemism for GnRH agonist, marketed in North America as Lupron, chemical name Leuprolide Acetate. Lupron is a synthetic analogue of GnRH, the hormone secreted by the hypothalamus for signalling the pituitary to excrete gonadotropins, which in turn signal the gonads to produce sex hormone. Sex hormones have a feedback effect on the brain—when sex hormone plasma levels are high then gonadotropin levels are low. Sex hormones have some involvement in a variety of endocrine functions, from neural to metabolic to immune. Lupron stops the cascading effect of hormonal signalling at hypothalamus. The analogue binds to the receptor in place of endogenous GnRH, severing the neural connection between the brain and the gonads.
Sex hormones have a neuroprotective effect | female physiology has complex sex hormone neuromodulation | estrogen may also have a neurorestrorative effect
Hormones are key in brain health differences between men and women, reports the American Heart Association. Sex hormones function not only as reproductive messengers but also as neuromodulators—powerful chemical signals that help neurons in the brain grow, prune themselves, and connect. Adolescents exhibit drastic and dramatic intense and erratic and often irrational and impulsive behaviour. Like the terrible twos, adolescence developmentally brings on profound changes in the brain. Growth of the amygdala, and synaptic changes therein, are amongst the functional brain changes that happen during puberty. We are used to thinking of sex hormones as important for fertility and reproduction. But hormones also play crucial roles in brain health, says Lisa Mosconi, Director of the Women's Brain Initiative at Weill Cornell Medicine in New York.
Estrogen is a well-known "master regulator" of the metabolic system of the female brain and body. Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial function to generate ATP in multiple brain regions involved in cognitive functions, such as medial temporal, posterior cingulate and frontal cortex, wrote Mosconi et al in their 2018 paper (access a copy below) on the connection between menopausal transition and Alzheimer’s Disease (AD). Depleted estrogen triggers functional changes in the brain. Women can experience noticeable neural changes such as decreased brain metabolism, shrinking hippocampus, and appearance of amyloid plaque that predicts AD. In fact Mosconi identified a unique neuroendocrine state during the transition from perimenopause to menopause that renders women particular vulnerable.
Preclinical studies identified the perimenopause to menopause transition, a neuroendocrine transition state unique to the female, as a sex-specific risk factor for AD. In animals, estro-genic regulation of cerebral glucose metabolism (CMRglc) falters during perimenopause.
In a 2017 study ( access a copy below) Mosconi et al found that women begin to experience a brain energy drop at the cellular level around menopause, triggered by the rapid hormone depletion related to the end of menarche. You can look at the papers, they have some technical neuroscience language. What’s the point of my neuroscientific elaboration? Dear reader, it’s to ask this — what are we doing to young brains of the pubescent children we are de-sexing under the guise of Gender Affirming Care? Nature’s de-sexing of the female brain brings profound changes, both felt and report by women and observed in brain scans.
What impact can we expect to see on young brains currently receiving 4 times the “safe limit” of the Hazardous Drug, anti-neoplastic + chemical castrating GnRH agonist which Gender Affirmationists call puberty blocker? Remember, according to John Geuriguian, former FDA officer, no one should receive more than the lifetime limit of 12 months. Also remember that GnRH agonist has four times the potency of endogenous GnRH. We are giving kids up to 48 months of GnRH agonist to affirm them.
Do clinicians promoting the Gender Affirming model of care know what they are doing to young brains they have decided to de-sex in their moral panic to affirm children who do not fit into their regressive sex role boxes which they call gender identity? Do we have any idea what will happen to these young people who have been affirmed to the point of a distorted synthetic menopause during puberty? According to Andrew and Tierney, (access paper below), estrogen has been described as being neuroprotective; this is thought to accrue through various mechanisms, including supporting growth and development of cholinergic neurons, increasing cholinergic activity, antioxidant properties, and alternative metabolism of amyloid.
Do we know what we are doing to these growing brains? In particular, do we know what we are doing to young female brains? Are we thrusting young girls and women into a distorted neuroendocrine state that will invite amyloid build-up and neurodegeneration related to impaired neuronal glucose metabolism? We need to be able to have a frank and open discussion about the neuroendocrine implications of de-sexing young girls with significant and often severe pre-existing neurobehavioural challenges When will the Repressive Tolerants allow us to talk about the iatrogenic abuse they continue to commit in the name of human rights?
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