De-Sexing Kids Will Stunt Their Brains
endogenous sex hormones are neuromodulators not toxins to suppress
sex hormones affect far more than just the sex organs
Puberty Blocker is the progressive euphemism for GnRH agonist, marketed in North America as Lupron, chemical name Leuprolide Acetate. Lupron is a synthetic analogue of GnRH, the hormone secreted by the hypothalamus for signalling the pituitary to excrete gonadotropins, which in turn signal the gonads to produce sex hormone. Sex hormones have a feedback effect on the brain—when sex hormone plasma levels are high then gonadotropin levels are low. Sex hormones have some involvement in a variety of endocrine functions, from neural to metabolic to immune. Lupron stops the cascading effect of hormonal signalling at hypothalamus. The analogue binds to the receptor in place of endogenous GnRH, severing the neural connection between the brain and the gonads.
Sex hormones have a neuroprotective effect | female physiology has complex sex hormone neuromodulation | estrogen may also have a neurorestrorative effect
Hormones are key in brain health differences between men and women, reports the American Heart Association. Sex hormones function not only as reproductive messengers but also as neuromodulators—powerful chemical signals that help neurons in the brain grow, prune themselves, and connect. Adolescents exhibit drastic and dramatic intense and erratic and often irrational and impulsive behaviour. Like the terrible twos, adolescence developmentally brings on profound changes in the brain. Growth of the amygdala, and synaptic changes therein, are amongst the functional brain changes that happen during puberty. We are used to thinking of sex hormones as important for fertility and reproduction. But hormones also play crucial roles in brain health, says Lisa Mosconi, Director of the Women's Brain Initiative at Weill Cornell Medicine in New York.
Estrogen is a well-known "master regulator" of the metabolic system of the female brain and body. Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial function to generate ATP in multiple brain regions involved in cognitive functions, such as medial temporal, posterior cingulate and frontal cortex, wrote Mosconi et al in their 2018 paper (access a copy below) on the connection between menopausal transition and Alzheimer’s Disease (AD). Depleted estrogen triggers functional changes in the brain. Women can experience noticeable neural changes such as decreased brain metabolism, shrinking hippocampus, and appearance of amyloid plaque that predicts AD. In fact Mosconi identified a unique neuroendocrine state during the transition from perimenopause to menopause that renders women particular vulnerable.
Preclinical studies identified the perimenopause to menopause transition, a neuroendocrine transition state unique to the female, as a sex-specific risk factor for AD. In animals, estro-genic regulation of cerebral glucose metabolism (CMRglc) falters during perimenopause.
In a 2017 study ( access a copy below) Mosconi et al found that women begin to experience a brain energy drop at the cellular level around menopause, triggered by the rapid hormone depletion related to the end of menarche. You can look at the papers, they have some technical neuroscience language. What’s the point of my neuroscientific elaboration? Dear reader, it’s to ask this — what are we doing to young brains of the pubescent children we are de-sexing under the guise of Gender Affirming Care? Nature’s de-sexing of the female brain brings profound changes, both felt and report by women and observed in brain scans.
What impact can we expect to see on young brains currently receiving 4 times the “safe limit” of the Hazardous Drug, anti-neoplastic + chemical castrating GnRH agonist which Gender Affirmationists call puberty blocker? Remember, according to John Geuriguian, former FDA officer, no one should receive more than the lifetime limit of 12 months. Also remember that GnRH agonist has four times the potency of endogenous GnRH. We are giving kids up to 48 months of GnRH agonist to affirm them.
Do clinicians promoting the Gender Affirming model of care know what they are doing to young brains they have decided to de-sex in their moral panic to affirm children who do not fit into their regressive sex role boxes which they call gender identity? Do we have any idea what will happen to these young people who have been affirmed to the point of a distorted synthetic menopause during puberty? According to Andrew and Tierney, (access paper below), estrogen has been described as being neuroprotective; this is thought to accrue through various mechanisms, including supporting growth and development of cholinergic neurons, increasing cholinergic activity, antioxidant properties, and alternative metabolism of amyloid.
Do we know what we are doing to these growing brains? In particular, do we know what we are doing to young female brains? Are we thrusting young girls and women into a distorted neuroendocrine state that will invite amyloid build-up and neurodegeneration related to impaired neuronal glucose metabolism? We need to be able to have a frank and open discussion about the neuroendocrine implications of de-sexing young girls with significant and often severe pre-existing neurobehavioural challenges When will the Repressive Tolerants allow us to talk about the iatrogenic abuse they continue to commit in the name of human rights?
RS: "Sex hormones function not only as reproductive messengers but also as neuromodulators—powerful chemical signals that help neurons in the brain grow, prune themselves, and connect."
Powerful drugs with far-reaching effects; rather presumptuous of us to be messing with them, particularly during the developmental processes of barely pubescent children. But fairly thorough analysis, though I wonder whether testosterone has similar regulatory effects:
https://en.wikipedia.org/wiki/Testosterone
But particularly liked your "de-sexing young girls" -- and young boys -- for calling a spade an effen shovel. Far too many of us don't have a flaming clue what odious crimes lurk beneath euphemisms like "gender-affirming care" and "sex-change operations". Case in point of the former in this tweet criticizing US representative Dan Crenshaw who was, quite reasonably, objecting to "doing a double mastectomy on a 12-year-old girl", to castrating a 10-year-old boy":
https://twitter.com/FPWellman/status/1680216416836804610
Though one might reasonably ask how accurate Crenshaw's examples were.
But a case in point of the latter is this Fox News segment with Laura Ingraham talking to a de-transitioner. Nice that Ingraham asks some pointed questions and argues that "gender affirming care" boils down into "mutilating children", as I think she put it. But what is rather "exasperating" is that Fox News has a headline under that story that asks, "Why is the left normalizing sex changes for kids?"
https://www.foxnews.com/media/progressive-journalist-breaks-left-warns-puberty-blockers-cause-irreparable-harm-children
But no human changes sex -- at least unless we're going to go with the Kindergarten Cop definitions: "boy's have penises and girls have vaginas". "Change your genitalia, change your sex! Act now! Offer Ends Soon!" 🙄 But by standard biological definitions for the sexes, such operations and procedures only "de-sex" children, just turn them into sexless eunuchs. Fine if adults want to do that to themselves for fun and profit. But to trick dysphoric and autistic children into doing so? Crime of the century.
However, such sloppy or self-serving language is, sadly, rather ubiquitous. Which is why it should be called out whenever and wherever it raises its noxious head. Case in point here in the context of a bit of good news:
"Female transgender athletes banned from women’s events by world cycling’s governing body
https://globalnews.ca/news/9833371/transgender-athletes-world-cycling-womens-races/
Global News: "Female transgender athletes who transitioned after male puberty will no longer be able to compete in women’s races, world cycling governing body the UCI said Friday."
Though I get quite peeved at phrasing like "female transgender athletes" -- they're male transvestites if they still have their nuts attached, and sexless eunuchs if they don't. Truth in advertising; "not through me":
https://www.goodreads.com/work/quotes/50709343-live-not-by-lies