Puberty Blockers Worsen Mood and Lead to Cognitive Impairment
GnRHa has a significant suppressive effect on serotonin transporter (SERT or 5-HTT), which reduces the amount of serotonin in the cells and synapses
First of all, let’s talk about the gender affirming care (GAC) protocol for paediatric patients. It’s based on the Tanner Stages of sexual development.
At Stage 2 kids will begin puberty blockade, meaning they’ll begin Gonadotropin-Releasing Hormone agonist (GnRHa) therapy. At Stage 5 they’ll begin “gender affirming hormone” therapy, meaning they’ll start taking cross sex hormones. Looking at the chart, we can calculate approximately 5 to 6 years between Tanner 2 and Tanner 5.
What kind of impact does chronic suppression of Gonadotropin Releasing Hormone have on the human body? How will this practically impact the kids following this treatment protocol?
First of all we need to remember the function of GnRH—it works to regulate the production of sex hormones through a mechanism called the hypothalamus-pituitary-gonadal (HPG) axis. Secreted from the hypothalamus, GnRH stimulates the release of Gonadotropins, released by the pituitary gland and called lutenising hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH work on the gonads (aka sex glands) to regulate gamete and sex hormone production. Sex hormones increase serotonin receptors levels—they upregulate serotonin.
Serotonin works in the brain to help neurons communicate with each other. It’s an important maintenance chemical, as you can see from the graphic.
So, what does this all mean?
Well, when we give a kid GnRHa for 5 years in a row without any add-back sex hormone, we have profoundly suppressed the hypothalamus-pituitary-gonadal (HPG) axis.
This has a significant impact on the brain, among the effects being low serotonin activity, a physiologic state that’s strongly linked to major depression, anxiety disorders, OCD, and suicidality.
In addition to depression, anxiety, emotional lability, irritability, and cognitive fog, chronic suppression of the HPG axis can lead to long-term changes in brain structure, specifically reduced hippocampal/amygdala volume. Reduced hippocampal/amygdala volume translates to difficulties with episodic + semantic + working memory, executive functioning impairment, as well as increased aggression and psychopathy.
But wait, there’s more. Other harmful effects of a chronically suppressed HPG axis include a changes in lipid profile (increased bad cholesterol and triglycerides and decreased good cholesterol), as well as increased insulin resistance. Cardiovascular risk rises. And then there’s the acceleration in bone density loss.
Screenshot: excerpt from an expert testimony given by Dr. John Geriguian, MD and pharmacology professor, in the Klein versus Abbot lawsuit.
“Lupron cannot be given more than 12 injections per lifetime.”
“Lupron is a powerful modulator of autonomic neural function.”
“Lupron suppresses the pituitary-gonadal system.”
“Synthetic [GnRHa] is many times more potent than the natural hormone and stays in the bloodstream longer.”
So, reader, “puberty blockers” sound pretty nasty, don’t they? Does it sound like anything you’d want your kid or grandkid to be taking? Why do gender radicals promote this hormone therapy protocol as an important life saving treatment option for kids experiencing pubertal angst? What, exactly do GAC activists think they’re affirmed by suppressing the HPG axis for 5 years in a row with a powerful pharmaceutical?
image: via CBC Kids News
How on earth does this treatment protocol relieve psychological distress or prevent psychiatric events? How on earth does it “save lives” of any kids? I’ve just explained how this treatment protocol does the opposite of what’s claimed. And we haven’t even gotten to the increased risk of diabetes and cardiovascular disease! And we’ve not even talked about the profound effects of bone density depletion.
image: a gender spectrum defining maximum femininity as “Barbie” and maximum masculinity as “G.I. Joe” via Ethical Legal Data Science, UC Berkeley School of Information
The more I learn about “puberty blockers,” the more horrified I become about the gender radical movement. How on earth is the UK conducting a clinical trial with this toxic stuff?