LupronGate Excerpt

Prologue + Introduction + an additional Excerpt

Prologue

I had never heard of Lupron before. I had no idea what Dr. Oakes had prescribed for me to take pre-ablation. No clue. She told me it would reduce the risk of bleeding, a concern for me because of my significant iron deficiency anemia. She did tell me are you sure you are done, you cannot undo this. She could have meant the ablation, a fancy term for laser-ing the lining of your uterus to hasten menopause, and she could have meant the Lupron. Combined, the two together spelled the permanent closure of my uterus for baby-making business. 

I had no idea she had prescribed a hormone agonist. Lupron sounded like some benign pharmaceutical that would reduce endometrial blood flow. I did not think because I trusted this doctor to do her own clinical thinking. I felt so anemic in those days I wanted to lick cast iron pans—at one point in my perimenopausal journey my haemoglobin was dangerously low at 11, so Lupron sounded ok if it helped me keep my iron levels from plummeting to those depths again. Lupron is the trade name for GnRH agonist. Agonist means working against, so like an anti-hormone. This means blocking a natural physiological process in body —like a chemical dam to stop the flow of a chemical or chemicals in a particular tributary of the body. GnRH agonist means blocking the flow of GnRH, which triggers the release of sex hormones — GnRH against means blocking the physiologic flow of sex at the brain. 

Dr. Oakes did not impress that upon me when she wrote that script and handed it to me. That seems kind of serious to mess around with a hypothalamic hormone for a surgical convenience. As I recall Dr. Oakes made the laser surgery sound risky and she made it sound like the Lupron could reduce the risk. She understated the risks of Lupron. She did not consider the risks for my particular patient profile — according to the AbbVie drug monograph for Lupron, someone with a history of psychiatric events makes a poor candidate for GnRHa therapy. I did not have a clue that Lupron had become the doorway to many women’s secret autonomic nervous system hell. It never occurred to me. A rare trusted doctor recommended Lupron and I didn’t question it. Dr. Oakes never warned me about the known severe autonomic side effects I could experience. It’s highly likely she did not know herself, thanks to a thing called Bahy-Dole. 

I only received two doses of Lupron and at one point I thought I would die, when inexplicably and temporarily I lost the ability to swallow and had to go to the ER twice in a week. The first time the male MD at St. Paul’s Hospital rolled his eyes and dismissed me with Benadryl. The second time, a few days later, the female MD at Vancouver General Hospital listened to me and gave me Decadron and had the respiratory therapist assess me for puffers and a chamber. The Decadron felt like very strong cocaine and the effect lasted for a few days and it felt unpleasant. 

I chalked up the strange physiologic effects I felt after receiving Lupron to menopause, remembering that my own mother struggled terribly with menopause at a time when hormone replacement therapy (HRT) did not exist as widely accessibly as it does today. I never for a moment imagined that the severe and sudden autonomic failure and challenge I experienced had anything to do with those 2 doses of Lupron given me. It never even occurred to me that a drug so powerful only certain nursing staff in the clinic can administer it would try to kill me in such a profoundly subversive manner. I only realised very recently, as in within the last few weeks, whilst compiling the research for this book, that my severe and debilitating symptoms most likely happened as a result of taking GnRHa. 

I fully recovered and I have no lasting effects, and this story of Lupron is not my story and I did not take an interest in Lupron for my own experience. That I have my own personal experience with Lupron seems to underscore the need to make this information widely available to the masses, to reach as many Canadians as possible. I have a nursing background and the capacity to conduct research and learn things and this book exists as a result. If I did not know about Lupron, and if I personally felt sidelined by the awful side effects, then how can anyone expect a child going through puberty would or could endure Lupron? I honestly wonder how many Canadians do not know what they do not know. How many doctors do not know what they do not know? How many parents? How many educators and allied professionals? 

In my research I discovered an entire treasure trove of evidence that Lupron has harmed many and that AbbVie and the FDA know about the harm and the falsification of and general weakness of the supporting clinical data. I also discovered that one of the most fiercely vocal opposers of Lupron, Dr. Rita Abend, simply vanished from the internet, only to reply “I don’t do that anymore” when an intrepid independent reporter tracked her down to ask her about her work gathering evidence of harm for victims of Lupron. The attempt to promote innovation through the marriage of science and industry has created a medical science landscape where health care has become iatrogenic harm and profits have become more important than people.

Regulators have become desensitized to the harm done to human beings. Doctors have become unwitting victims or deliberate accomplices of the system created by medical science and research controlled by profit incentive and not human progress. Some of us who have awareness of the dangers of Lupron still cling to an idealistic naïveté that pointing out the harm or opposing Lupron in the current antagonistic political process will have any kind of long lasting impact. I encounter many on the frontlines who still believe that we only need to reveal the harm done and everything will magically end and get fixed. The more I dive into Lupron and learn about GnRHa, the more I see misguided nature of this vision. 

Look at the Sec 10-K Reports for AbbVie, a thoughtful and sensible American clinical psychologist recently hinted in a discussion about puberty blockers. I took that advice. I took a peak at the Sec 10-K reports. You know what I found, just on initial inspection? Lupron is the most versatile product in AbbVie’s drug portfolio. Anti-neoplastic, fertility drug, Central Precocious Puberty suppressant, endometriosis treatment, prophylaxis to prevent bleeding for uterine ablation and fibroid removal — that seems like a dream pharmaceutical, doesn’t it? When you consider that patents for it’s biggest money making drug will expire soon, AbbVie likely has no interest in protecting children with depression + anxiety + post trauma stress + “gender dysphoria” as well as women with endometriosis, from severe the iatrogenic harm of Lupron chemotherapy.  

On September 18th, 2023, CBC published a piece written by Paige Parsons entitled, Trans teens and youth say gender-affirming care is 'life-changing.' So why is it so hard to find in Canada? When the state-funded broadcaster promotes a severe cult-like bias on a vital political, social and health care issue, I believe it’s time for independent researchers and writers and journalists to buckle up and somehow find a way to get the facts to the people on the ground. I think far more than “gender ideology”,  “queer theory”, or “cultural Marxism” or “postmodernism” drives the demand for synthetic children and Lupron as a means to create those synthetic children. I hope I can elucidate some of the forces I have observed over the past several years driving this movement, through my work on LupronGate. 

Introduction

In the early 1970s GnRH analogue made a revolutionary impact when it provided a safe and effective alternative to surgical amputation of the testicles, known as orchiectomy or simply, castration. Analogue means synthetic formulation of an endogenous hormone. Hormone means a chemical secreted by a gland, defined as a body of secreting cells. Lupron originally and primarily prevented surgical removal of the genitals. Licensed as an anti-neoplastic, GnRH analogue worked by preventing the secretion of endogenous sex hormones, starving the gonads, and shrinking them. Most importantly, GnRH analogue worked by starving malignant cells that need sex hormones to survive and grow. GnRH analogue has an nearly identity chemical signature as GnRH made by the hypothalamus, with a small tweak that enables it to mimic GnRH enough to occupy the receptor at the cellular level and that’s different enough to shut down sex hormone production at its neuronal source. 

Today a major off-label use of Lupron involves treating children with emotional dysregulation and dissociative disorders to induce pubertal suppression, in tandem with synthetic cross sex hormones, which induces an opposite sex puberty. This inevitably leads to a clinical outcome that almost always necessitates surgical removal of the sex organ, aka gonads. Read that again. Today, a major off-label use of Lupron involves stopping sexual maturity in children in order to turn them in to asexual blanks onto which doctors can force a false sexual maturity with opposite sex hormones. Lysenko tried to make spring wheat into winter wheat and GenderWang doctors try to make girls into boys and boys into girls. Lysenko destroyed a lot of important research work and hopefully GenderWang does not create the same damage. Mary Shelley’s great work provides a more tragic and poetic analogy, perhaps. The arrogance of doctors who lack the moral compass for their position harm the innocent.

The dominant dualistic philosophy that guides western medicine, i.e. mind versus body, has rendered our society vulnerable to cult movements such as the GenderWang movement. GenderWang advances the Harry Benjamin argument that medicine must make the body match or conform to the mind. Affirmation therefore happens when doctors make the body match the feeling about the body. Gender Affirming Care describes the industry of medical care which has built itself around providing experimental medical care to children experiencing puberty in order to make their bodies match their thoughts about their bodies. 

People genuinely believe the story that a child can receive this miracle drug which will “pause” their natural growth without effect so they can be a kid a bit longer and decide whether they like their natural sex or want to have a synthetic one instead. Parents and teachers and doctors too all believe that the paediatric endocrine system can function like Netflix show you watch and pause to get a snack and then unpause with no disruptions or ill effects. It betrays a deep ignorance about the human body and human sexuality. Kids now seem like streaming social media platforms, you can plug and play and switch programmes anytime you feel like it. Affirming thoughts, no matter how bizarre and unhinged, has now become an objective of medical care.  

I began this research in response the bewildering cult of body modification identity that has swept across Canada like a powerful religion. I found it absolutely baffling that legislators embedded a concept into the human rights codes across the country which essentially has no definition beyond the thoughts and feelings individual has about their reproductive class. I continued to find it baffling when I watched 338 seemingly intelligent humans purporting to represent Canadian voters pass legislation  that makes “gender identity conversion therapy” illegal because they want to ban gay conversion therapy. Do we know what specifically gender identity conversion therapy looks like or means? Do the MPs who voted to make gender identity conversion therapy illegal have a clear conception of what they criminalised? What does gender identity conversion therapy look like? Can any of the MPs who voted YEA tell me what they stopped by passage of that law? I continue to wonder what the heck is going on, as I watch public sector unions gather and castigate concerned parents as fascists and bigots. “Gender identity conversion therapy” does not exist except in the minds of zealots who treat puberty like a disease and dissociation like an identity that needs human rights protection. Parental inclusion does not limit a child’s rights, in fact it ensures and protects them. 

The mainstream media long ago abrogated its duty to inform the Canadian pubic. Today, and for several years now, the media in Canada chooses to misinform and manipulate when it comes to the topic of puberty suppression and gender affirmation offered as a solution for children. So, I decided to learn about Lupron out of necessity — if you want something done and all that. What I uncovered shocked me. Drug companies routinely take risks with human lives. They choose profit over person — why remove a product from the market when you can lawyer up and then throw money at the problem repeatedly? 

I began writing this body of work as a report and one third of the way through it became apparent LupronGate will end up more than a report — it will become a book. LupronGate: The Truth About Puberty Blockers explores the origin story and reality of puberty blockers. What are puberty blockers? What do we know about them? Are they safe? Reversible? Gender doctors tell patients and their parents they have nothing to worry about when it comes to puberty blockers. Why don’t we hear more balanced stories in the mainstream news media about the dangers of puberty suppression? Why does the ACLU oppose mandatory chemical castration of pedophiles and sex offenders and also promote the mandatory chemical castration of kids with psychiatric distress? Why have we regressed back to Victorian times, when doctors treated mood disorders in women by giving them hysterectomies and conducting reproductive experiments on them? Did you know Canada led the world in that medical practise? Why do we forget history — this dooms us to repeat it, doesn’t it? Why do we live like tea bags steeping in a brew of obvious lies conjured by industry and its accomplices? 

LupronGate explores the origin story of Lupron and it’s profile as a pharmaceutical, the business landscape that medical research and pharmaceutical regulations exists within, the development of child psychiatry as a medical field and also an industry, and the origin story of pubertal suppression as a treatment regime in for children diagnosed with a questionable psychiatric disorder. LupronGate explores the origin story of the questionable psychiatric disorder — Gender Dysphoria. LupronGate explores the discovery of sex hormones and reveals some of the animal and human experimentation it triggered, in addition to insight about the the men who conducted these experiments. Finally, LupronGate will provide a picture of the degree of accessibility of Lupron in Canada —what system exists in Canada to provide Gender Affirming Care to kids? How easily can an impulsive kid get access to Lupron? How much power do parents have to stop their impulsive children from taking Lupron? LupronGate will explore the capture of all medical and allied professions by GenderWang and the very weak evidence they rely upon.

“Puberty Blockers” Means Chemical Castration

“The experiment should be such as to yield fruitful results for the
good of society, unprocurable by other methods or means of study,
and not random and unnecessary in nature.”

— Nuremberg Code "Permissible Medical Experiments." Trials of War Criminals before the Nuremberg Military Tribunals under Control Council Law No. 10.

Chemical castration severs the connection between the sex organs and the brain. We see the obvious sexual and physical effect of rupturing the axis connecting the hypothalamus and the gonads and that overshadows the invisible effects of chemical castration. Hormones drive brain health differences between men and women, according to the American Heart Association. 

Estrogen is a well-known "master regulator" of the metabolic system of the female brain and body. Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial function to generate ATP in multiple brain regions involved in cognitive functions, such as medial temporal, posterior cingulate and frontal cortex, wrote Mosconi et al in their 2018 paper on the connection between menopausal transition and Alzheimer’s Disease (AD). Depleted estrogen triggers functional changes in the brain. Women can experience noticeable neural changes such as decreased brain metabolism, shrinking hippocampus, and appearance of amyloid plaque that predicts AD. 

In fact in her research Mosconi identified a unique neuroendocrine state during the transition from perimenopause to menopause that renders women particular vulnerable. Preclinical studies identified the perimenopause to menopause transition, a neuroendocrine transition state unique to the female, as a sex-specific risk factor for AD. In animals, estrogenic regulation of cerebral glucose metabolism falters during perimenopause. Women begin to experience a brain energy drop at the cellular level around menopause, triggered by the rapid hormone depletion related to the end of menarche. Pituitary desensitization without a feedback loop from the gonads (ie in the case of chemical castration or menopause) results in a higher plasma level of FSH (because it has a higher half life than does LH) — FSH levels have an inverse correlation with mood — higher levels of FSH have an association with low mood such as depression + anxiety + irritability.

What does this mean in plain language? It means that shutting off the sex hormone tap in the brain of children the way the Gender Affirming Care does could trigger a decline in brain metabolism, it could put them at risk for cognitive decline, it could impair their glucose metabolism, it will almost certainly create chemical changes that result in decreased mood. Nature has constructed itself with mechanisms to self regulate, to promote homeostasis, the natural state of balance of all things. The neuroendocrine system functions this way — with checks and balance. It means Gender Affirming Care zealots have disturbed a hornets nest without having any idea what they have done and without any plan to fix the fallout.  In fact Susan Bradley, a pioneer in the field of paediatric gender medicine, now admits that pubertal suppression did indeed have harmful long term effects. We now have sufficient evidence to prove the iatrogenic harm of puberty blockers. We now go forward knowing fully that anyone still promoting puberty blockers to kids and their parents and teachers as the panacea to childhood trauma and pubertal angst and even eating disorders that plague adolescent girls promotes an unattainable objective and panacea, also a negligent one. 

We are used to thinking of sex hormones as important for fertility and reproduction and we ignore the crucial role  hormones play in brain health. Artificially manipulating hormone levels in adolescent brains will indeed have irreversible effects — puberty blockers cannot possibly be harmless and reversible, as Jack Turban, Tyler Black, Meridithe McNamara and the Paediatric Gender Affirming Care zealots claim. Tinkering with GnRH hormone production + secretion in the body has a far more complex and diffuse effect than the mere shutting off of sex and making a human into a perfectly asexual blank onto which any gender identity can stamp itself via synthetic hormones mass produced by powerful and bloated pharmaceutical companies. 

The medical and allied professionals promoting puberty blockers as harmless and reversible really have no idea how Gender Affirming Care will impact kid’s brains. Chemical castration of children for the purposes of synthetically transforming them into the opposite sex will not relieve any emotional distress they have over the long term, it has no long term benefit to the child, nor to the larger society. Pubertal suppression advances no clinical scientific objective. It does not meet the criteria set out by the Nuremberg Code. 

Gender Affirming Care zealots take children who have a complex psychiatric profile that includes suicidality and they treat them with GnRH agonist and they call it life-saving and they call it affirming an innate identity.  What human being has an innate identity that requires that human to chemically and surgically destroy their physical form in order to survive and thrive in existence and life? Read that sentence and think carefully what it asks you. Then ask yourself what is a trans kid, why do you expect me to believe that stopping a natural growth process in a child will be the life saving long term solution for this child? 

Zealots promoting Gender Affirming Care have concocted dramatic and elaborate lies to justify experimenting on very vulnerable children, some with developmental disabilities and challenges such as autism. Poor study design and cumbersome statistical methods that amount to torturing data sets to render the desired outcome dominate the field of paediatric gender medicine. Certainly hundreds of studies exist to extoll the virtues of paediatric Gender Affirming Care, none of them valid and reliable, none of them able to provide causative evidence of the efficacy of puberty blockers to prevent kids from suffering depression, anxiety, and suicidal ideation and behaviour.  

I have questions about “puberty blockers” and gender affirming chemotherapy in general. 

1. How does a gender affirmation chemotherapy regime of GnRH agonist puberty suppression + cross sex hormone therapy impact functional restructuring of an adolescent brain? 

2. How does desensitising hypothalamic GnRH neurons impact the kisspeptin neurons? 

3. How does suppressing endogenous sex hormone and elevating cross sex hormone impact kisspeptin neurons and the feedback mechanism? How do we account for the impact of circulating gonadotropins on psychological wellbeing? 

4. What will happen to these young people who have been “gender affirmed” to the point of a distorted synthetic menopause during puberty?

Go back a few paragraphs and reread and review what I wrote. FSH levels have an inverse correlation with mood. Think about what it means. High unchecked levels of FSH mean low mood—FSH drives depressed mood and irritability and anxiety. So women, think about your menstrual cycle. You know when you are PMSing in that awful week or two of your menstrual cycle and you feel angry and irritated and sad and hateful from the inside of your body, like you want to set stuff on fire and fiddle whilst it burns? That is FSH rising creating those icky and unpleasant emotions. Now think about the fact that puberty blockers does this to children already struggling with emotional regulation issues and crises in their lives. Also consider that we don’t know how long it lasts and what other cascading effects will happen. Does that sound affirming to you? It doesn’t sound affirming to me. 

Researchers only recently discovered the Kisspeptin Protein and its neural signalling mechanism, so we obviously have not considered how gender affirming care modulates Kisspeptin signalling and how this will impact children taking Lupron in the long term. There is so much we do not know. We presume a great deal. We have chosen to discard all we know about paediatric physiological development, about basic human reproduction. Why? What if we thought of the pubertal intersection of reproductive and neuroendocrine biochemistry as a very complex spaghetti junction in a motorway?